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KMID : 0356420060240010008
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Journal of Korean Andrology
2006 Volume.24 No. 1 p.8 ~ p.12
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Tamoxifen Only versus L-Carnitine and Tamoxifen in the Oral Therapy of Peyronie’s Disease
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Yoon Chang-Jun
Moon Ki-Hak
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Abstract
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Purpose: To evaluate the effects of oral Tamoxifen only versus L-Carnitine plus Tamoxifen in patients with Peyronie’s disease.
Materials and Methods: All 45 patients with Peyronie’s disease, diagnosed using accepted definitions, were randomized into two groups and treated for 3 months with Tamoxifen only(40 mg/day)(n=17) or a combination ofL-Carnitine(2 g/day) and Tamoxifen(40 mg/day)(n=28). A medical history was obtained, and a physical examination was performed. Plaque size, pain, erectile function(IIEF score), and penile curvature were assessed. Both before and after therapy, the differences between the 2 groups were compared using independent-sample t-test with p＜0.05 considered significant.
Results: The mean age of the 45 patients was 52.1 years, and no severe adverse events occurred in either group. In the Tamoxifen only group, the mean decrease of plaque-length was 0.46±0.88 mm, and mean reduction in the pain rating scale was 0.44±0.53. In the L-Carnitine and Tamoxifen group, mean decrease of plaque-length was 1.57±0.92 mm, and mean reduction in the pain rating scale was 1.27±0.96. Based on IIEF scores, the improvement of erectile function was 0.88±0.64 in the Tamoxifen only group and 1.56±0.75 in the L-Carnitine and Tamoxifen group. The degree of penile curvature was also measured, and the reduction of curvature angle was 9.17±4.92o in the Tamoxifen only group and 9.55±6.50o in the L-Carnitine and Tamoxifen group.
Conclusions: This study showed significantly greater improvements in plaque size, pain, erectile function, and curvature in patients with Peyronie’s disease who were treated with L-Carnitine and Tamoxifen compared with those treated with Tamoxifen only.
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KEYWORD
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Peyronie’s disease, Tamoxifen, Carnitine
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